P-glycoprotein (P-gp/ABCB1) is a typical type of multiple drug resistance (MDR) transport protein that can recognize and promote the drug efflux of tumor cells, severely limiting the efficacy of anti-tumor drugs.
Bio & Medicine
May 12, 2023
0
4
Deep space is most likely going to be humanity's final frontier, and space travel will undoubtedly become much more common in the future. However, space is a very hostile environment not only because of the technical difficulties ...
Space Exploration
Sep 13, 2021
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13
Many processes in the body are regulated by the functions of proteins. For example, almost all molecules—such as DNA, proteins, oligosaccharides, and small bioactive molecules—are generated by enzymes. However, changes ...
Biochemistry
Aug 10, 2021
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311
Multidrug resistance (MDR)—a process in which tumors become resistant to multiple medicines—is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that ...
Bio & Medicine
Oct 16, 2020
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127
Pity the glycan—these complex sugar molecules are attached to 80% of the proteins in the human body, making them an essential ingredient of life. But this process, known as glycosylation, has been somewhat overshadowed ...
Biochemistry
Sep 17, 2020
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97
Cell therapies hold great promise for revolutionizing the treatment of cancers and autoimmune diseases. But this multibillion-dollar industry requires long-term storage of cells at super-cold cryogenic conditions, while ensuring ...
Biochemistry
Feb 14, 2020
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142
Vanderbilt University researchers have discovered how a protein pump distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
Biochemistry
May 31, 2019
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15
Cancer drops sparse chemical hints of its presence early on, but unfortunately, many of them are in a class of biochemicals that could not be detected thoroughly, until now.
Biochemistry
May 7, 2018
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217
Scientists have identified a unique molecular binding mechanism that helps keep non-mammalian creatures in sub-zero temperatures from freezing. Antifreeze glycoproteins (AFGPs), produced by polar fishes, inhibit ice growth ...
Biochemistry
Apr 20, 2018
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10
The structure of the critical quality control checkpoint enzyme that oversees the production of thousands of secreted glycoproteins has been solved by a fruitful collaborative effort at Diamond Light Source. The study, recently ...
Biochemistry
Jul 25, 2017
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90
Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending extracellularly, the extracellular segments are often glycosylated. Glycoproteins are often important integral membrane proteins, where they play a role in cell–cell interactions. Glycoproteins also occur in the cytosol, but their functions and the pathways producing these modifications in this compartment are less well-understood.
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